Less than twenty-four hours after City's 1-1 draw at Notts County, Parkinson's men will set off on their travels again on Sunday as they prepare for their eagerly-anticipated encounter at the Madejski Stadium.
The prize for the victors on Monday night is, of course, a trip to Wembley Stadium to play FA Cup holders Arsenal in the last four.
With new loan signing Jak Alnwick cup-tied, Ben Williams is set to return back in goal, while City will need to check again on Andrew Davies after he was rested at Meadow Lane due to a recent arm injury.
Parkinson said: "We did contemplate staying down the Saturday night after the Notts County match but I remember as a player and as a manager that sometimes you can have too long in a hotel waiting for a game.
"It is sometimes better to keep things fresh.
"We will be travelling down Sunday, training at St George's Park along the way, and then get down to our hotel base Sunday evening.
"For me personally, it will obviously be special to go back to Reading - I have a lot of fond memories from my time there - but obviously the main focus is on the prize of playing Arsenal in the FA Cup Semi Finals.
"We are really looking forward to this one. We will have a meeting with the staff in the hotel on Sunday night to decide what team we will pick for what will be an unbelievable occasion.
"I'm sure it will be a cracking atmosphere around the ground on Monday night and we can't wait for it."