After two narrow defeats on the road at the hands of Swindon Town and Peterborough United last week, Parkinson's men return to the Coral Windows Stadium on Tuesday evening looking to keep in touch with the top six.
Top scorer James Hanson could return to the side after three games out with a hamstring injury but Gary Liddle is still out through suspension.
While Hanson's possible recall could be seen as expected though, Parkinson has strongly hinted that he could also look to include players who haven't featured too heavily this season for the Crawley fixture.
Parkinson said: "We are going to make a few changes on Tuesday night - I just felt we looked a bit stale on Saturday.
"We need to shake the pack up a bit and that is what we intend to do.
"There are a few players who have been waiting patiently for a chance and I want to try and get the freshness back into the dressing room.
"There are a few other reasons for these changes as well.
"We have to think of what is coming up at the weekend (Reading, F.A Cup Quarter Final), what league games we have coming up quickly afterwards and also the amount of games we have already played recently.
"We need to re-energise the group. There are some players who have been waiting a long time for a game and there are others who have virtually played in every match and who might need a rest.
"We are obviously disappointed to lose these last two away games - we've had a great record on our travels mainly this season - but I just felt we were flat on Saturday.
"There wasn't a lack of energy or commitment - the lads gave us everything - we just lacked that little bit of spark in our play.
"I had a meeting with the staff today (Monday) and they all felt the same.
"It is up to us now to pick a team to get us going again."
Tuesday's Crawley match will be the first of two home games for City this week, with the club's eagerly-anticipated F.A Cup Quarter Final against Reading set for this coming Saturday.
Parkinson added: "We want to go into Saturday on a positive note - every game is important to us now at this part of the season.
"We will be able to enjoy the occasion on Saturday so much more if we can achieve a good result on Tuesday.
"There will be a few players out there on Tuesday who haven't played a lot of football this season and it would be great if the supporters could give them a chance and really get behind them. I am sure they will.
"As a group of players, staff and other team members, we stick together and we work for each other.
"We've had some members of that group drive up and down the country to give their support to the lads in the dressing room or perhaps to be an unused substitute and now they are going to get their chance."